Neoadjuvant chemotherapy with dose-dense MVAC in muscle-invasive bladder cancer: a tertiary center experience

Purpose Neoadjuvant chemotherapy in muscle-invasive bladder cancer (MIBC) patients has proven beneficial in overall survival. However, the optimal regimen is still a matter of debate. Materials and method In this retrospective analysis, we evaluate the results obtained in 42 patients treated in our center with 4 cycles of neoadjuvant dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (dd-MVAC) followed by radical cystectomy from August 2015 to October 2020. All patients had cT2 or higher non-metastatic MIBC. Clinical and pathological outcomes are reported. Results Of the 42 patients, 90.5% were men (n = 38) and the mean age was 65 years. All of them had ECOG 0–1 at diagnosis and most tumors had an initial clinical stage T2N0 (76%). Thirty-six patients (85.7%) completed 4 cycles of neoadjuvant treatment, and 21.4% required a dose reduction. The most frequent adverse event (AE) was grade 1–2 asthenia (81%), while neutropenia was the most frequent grade 3 or higher AE (38%). Complete pathological response (ypT0, ypN0) was achieved in 50% of patients (n = 21), and down-staging was observed in 57.1% (n = 24). Only one patient presented radiological progressive disease during neoadjuvant treatment (2.4%), and after a mean follow-up time of 31.5 months, 33.3% of patients experienced disease recurrence. Conclusions Neoadjuvant chemotherapy with 4 cycles of dd-MVAC is an effective regimen with high rates of pathological complete responses and down-staging along with an acceptable toxicity profile. DD-MVAC should be considered as an alternative to cisplatin and gemcitabine in patients with good clinical performance status (AU)

Neoadjuvant chemotherapy with dose-dense MVAC in muscle-invasive bladder cancer: a tertiary center experience.

PURPOSE: Neoadjuvant chemotherapy in muscle-invasive bladder cancer (MIBC) patients has proven beneficial in overall survival. However, the optimal regimen is still a matter of debate. MATERIALS AND METHODS: In this retrospective analysis, we evaluate the results obtained in 42 patients treated in our center with 4 cycles of neoadjuvant dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (dd-MVAC) followed by radical cystectomy from August 2015 to October 2020. All patients had cT2 or higher non-metastatic MIBC. Clinical and pathological outcomes are reported. RESULTS: Of the 42 patients, 90.5% were men (n = 38) and the mean age was 65 years. All of them had ECOG 0-1 at diagnosis and most tumors had an initial clinical stage T2N0 (76%). Thirty-six patients (85.7%) completed 4 cycles of neoadjuvant treatment, and 21.4% required a dose reduction. The most frequent adverse event (AE) was grade 1-2 asthenia (81%), while neutropenia was the most frequent grade 3 or higher AE (38%). Complete pathological response (ypT0, ypN0) was achieved in 50% of patients (n = 21), and down-staging was observed in 57.1% (n = 24). Only one patient presented radiological progressive disease during neoadjuvant treatment (2.4%), and after a mean follow-up time of 31.5 months, 33.3% of patients experienced disease recurrence. CONCLUSIONS: Neoadjuvant chemotherapy with 4 cycles of dd-MVAC is an effective regimen with high rates of pathological complete responses and down-staging along with an acceptable toxicity profile. DD-MVAC should be considered as an alternative to cisplatin and gemcitabine in patients with good clinical performance status.

Bladder Capacity in Women With Overactive Bladder Syndrome: A Cross-sectional Study.

OBJECTIVE: To evaluate bladder capacity in women with idiopathic overactive bladder syndrome (OAB) through bladder diary, cystomanometry, and uroflowmetry and assess the concordance of the different measures of bladder capacity. A secondary objective is to describe the relationship between bladder capacity and urinary frequency in OAB patients. METHODS: An observational cross-sectional multicentric study was conducted, including female patients diagnosed with idiopathic OAB. All participants underwent a urodynamic study and completed a 3-day bladder diary (3dBD). Different parameters were used to calculate bladder capacity: maximum cystometric capacity (MCC) assessed at the end of filling cystometry, voided volume (VV) during the uroflowmetry, maximum voided volume (VVmax), and average voided volume (VVmed), both assessed through the 3dBD. Reproducibility analysis was performed to assess the agreement among the different bladder capacity measures. Intraclass correlation coefficient (ICC) and weighted Kappa index were used. Bladder capacity parameters were also assessed in relation to urinary frequency. RESULTS: Bladder capacity measures were diminished in this population, except for VVmax. Poor correlation was found between the different bladder capacity variables (ICC and weighted Kappa index <0.4). Twenty-four-hour frequency and average VV present a weak negative linear relationship (Pearson coefficient -0.344). CONCLUSION: MCC and average VV are reduced in OAB patients. MCC does not correlate well with functional bladder volumes determined by voiding diary in the OAB population.

Gold Glyconanoparticles Combined with 91-99 Peptide of the Bacterial Toxin, Listeriolysin O, Are Efficient Immunotherapies in Experimental Bladder Tumors.

This study presents proof of concept assays to validate gold nanoparticles loaded with the bacterial peptide 91-99 of the listeriolysin O toxin (GNP-LLO91-99 nanovaccines) as immunotherapy for bladder tumors. GNP-LLO91-99 nanovaccines showed adjuvant abilities as they induce maturation and activation of monocyte-derived dendritic cells (MoDCs) to functional antigen-presenting cells in healthy donors and patients with melanoma or bladder cancer (BC), promoting a Th1 cytokine pattern. GNP-LLO91-99 nanovaccines were also efficient dendritic cell inducers of immunogenic tumor death using different bladder and melanoma tumor cell lines. The establishment of a pre-clinical mice model of subcutaneous BC confirmed that a single dose of GNP-LLO91-99 nanovaccines reduced tumor burden 4.7-fold and stimulated systemic Th1-type immune responses. Proof of concept assays validated GNP-LLO91-99 nanovaccines as immunotherapy by comparison to anti-CTLA-4 or anti-PD-1 antibodies. In fact, GNP-LLO91-99 nanovaccines increased percentages of CD4+ and CD8+ T cells, B cells, and functional antigen-presenting DCs in tumor-infiltrated lymphocytes, while they reduced the levels of myeloid-derived suppressor cells (MDSC) and suppressor T cells (Treg). We conclude that GNP-LLO91-99 nanovaccines can work as monotherapies or combinatory immunotherapies with anti-CTLA-4 or anti-PD-1 antibodies for solid tumors with high T cell infiltration, such as bladder cancer or melanoma.

Sexual function after anterior urethroplasty: a systematic review.

BACKGROUND: Urethral surgery outcomes are often evaluated by assessing urinary flow and urethral patency. However, sexual consequences may appear after urethroplasty, impairing quality of life and patient's perception of success.The aim of this study is to assess the relationship between anterior urethral reconstruction and postoperative sexual dysfunction, including the proposed factors predicting sexual outcomes. METHODS: We searched in PubMed database using the terms: "anterior urethroplasty", bulbar urethroplasty" or "penile urethroplasty", and "sexual dysfunction", "erectile function" or "ejaculation". Articles were independently evaluated for inclusion based on predetermined criteria. Systematic data extraction was followed by a comprehensive summary of evidence. RESULTS: Thirty-eight studies were included for final analysis. No randomised trial on the topic was found. Urethral surgery might affect different aspects of sexual function: erectile function, ejaculatory function, penile shape and length, and genital sensitivity, leading to severe sexual dysfunction. Patient perception of sexual impairment was related to post-operative satisfaction. CONCLUSIONS: Sexual dysfunction after anterior urethral reconstruction is an important issue that must be appropriately discussed during preoperative patient counselling. Reported outcomes after anterior urethroplasty should include sexual consequences and relevance, evaluated using validated tools.

Síndrome de Zinner en un paciente politraumatizado / Zinner's syndrome in a polytrauma patient

Objetivo: Reportar dos nuevos casos de Síndrome de Zinner, una variante anatómica poco prevalente y conocida, con riesgo de originar alteraciones. Método: Descripción de dos casos de Síndrome de Zinner presentados en nuestro centro, durante estudio por epididimitis aguda de repetición y tras traumatismo renal grado IV. Revisión de la literatura hasta la fecha, centrada en su diagnóstico y posibles complicaciones. Resultado: El manejo conservador del paciente politraumatizado permitió preservar el riñón, manteniendo una función renal normal. Es el primer caso de síndrome de Zinner diagnosticado en este contexto clínico. Conclusiones: El Síndrome de Zinner es una entidad poco frecuente y que pasa inadvertida en muchas ocasiones dada la escasa sintomatología que produce

Objective: To report two Zinner's syndrome cases, a rare anatomical variant with risk of complications. Methods: Analysis of two Zinner syndrome cases, detected during acute recurrent epididimytis and after a grade IV renal trauma. Review of the literature focusing on its diagnosis and possible complications. Results: The conservative management of the polytrauma patient allowed to preserve the kidney, while maintaining normal renal function. It is the first Zinner`s syndrome diagnosed in this clinical context. Conclusions: Zinner`s syndrome is a rare entity and often goes unnoticed because of the few symptoms it produces

[Zinner`s syndrome in a polytrauma patient.] / Síndrome de Zinner en un paciente politraumatizado.

OBJECTIVE: To report two Zinner`s syndrome cases, a rare anatomical variant with risk of complications. METHODS: Analysis of two Zinner syndrome cases, detected during acute recurrent epididimytis and after a grade IV renal trauma. Review of the literature focusing on its diagnosis and possible complications. RESULTS: The conservative management of the polytrauma patient allowed to preserve the kidney, while maintaining normal renal function. It is the first Zinner`s syndrome diagnosed in this clinical context. CONCLUSIONS: Zinner`s syndrome is a rare entity and often goes unnoticed because of the few symptoms it produces.

OBJETIVO: Reportar dos nuevos casos de Síndrome de Zinner, una variante anatómica poco prevalente y conocida, con riesgo de originar alteraciones. MÉTODO: Descripción de dos casos de Síndrome de Zinner presentados en nuestro centro, durante estudio por epididimitis aguda de repetición y tras traumatismo renal grado IV. Revisión de la literatura hasta la fecha, centrada en su diagnóstico y posibles complicaciones. RESULTADO: El manejo conservador del paciente politraumatizado permitió preservar el riñón, manteniendo una función renal normal. Es el primer caso de síndrome de Zinner diagnosticado en este contexto clínico. CONCLUSIONES: El Síndrome de Zinner es una entidad poco frecuente y que pasa inadvertida en muchas ocasiones dada la escasa sintomatología que produce.

[Mini-laparoscopic pyeloplasty.] / Pieloplastia por Minilap..

Continued progresses in the field of laparoscopy have been introduced in urological surgery. With the development of smaller instrumental minilaparoscopy was born seeking to reduce abdominal trauma and improve cosmetic scars, obtaining similar or better results than conventional laparoscopy. OBJECTIVE: The objective of this paper is to evaluate the results and reproducibility of mini-laparoscopic pyeloplasty. METHODS: A literature review and a bibliographic search in PubMed were performed. We describe the technique used in the "Hospital Marqués de Valdecilla" (HUMV), Santander (Spain). RESULTS: 60 articles about mini-laparoscopy were found. Although there are few reported minilap pyeloplasty series, they offer excellent cosmetic and functional results. We analyze operative time, complications, postoperative hospital stay, conversion rate, functional and cosmetic results, and we compare them with conventional laparoscopic pyeloplasty. CONCLUSIONS: More reported series are necessary but it has been proved that minilap pyeloplasty is a reproducible and safe technique with excellent results.

Pieloplastia robótica y laparoscópica / Robot-assisted and laparoscopic pyeloplasty

Los continuos avances en el campo de la laparoscopia han ido siendo introducidos progresivamente en la cirugía urológica. Con el desarrollo de instrumental de menor tamaño nace la minilaparoscopia, buscando reducir el trauma abdominal y mejorar la cosmética de las cicatrices, obteniendo unos resultados similares o mejores a los logrados en la laparoscopia convencional. Objetivo: El objetivo es evaluar los resultados y la reproducibilidad de la pieloplastia por minilap. Método: Para ello se ha realizado una revisión de la literatura y una búsqueda bibliográfica en PubMed. Describimos la técnica quirúrgica realizada en el Hospital Universitario Marqués de Valdecilla, Santander (HUMV). Resultados: se encontraron más de 60 artículos que hacían referencia a la minilaparoscopia. Aunque a día de hoy son escasas las series reportadas de pieloplastia por minilap, estas ofrecen unos resultados excelentes. Analizamos los datos de tiempo quirúrgico, complicaciones, estancia hospitalaria, tasa de conversión, resultado funcional y cosmético, comparándolos con la pieloplastia laparoscópica convencional. Conclusiones: Aunque es necesario que se reporten más series, se ha demostrado que la pieloplastia por minilap es una técnica reproducible y segura, que otorga así mismo unos resultados excelentes

Continued progresses in the field of laparoscopy have been introduced in urological surgery. With the development of smaller instrumental minilaparoscopy was born seeking to reduce abdominal trauma and improve cosmetic scars, obtaining similar or better results than conventional laparoscopy. Objective: The objective of this paper is to evaluate the results and reproducibility of mini-laparoscopic pyeloplasty. Methods: A literature review and a bibliographic search in PubMed were performed. We describe the technique used in the Hospital Marqués de Valdecilla (HUMV), Santander (Spain). Results: 60 articles about mini-laparoscopy were found. Although there are few reported minilap pyeloplasty series, they offer excellent cosmetic and functional results We analyze operative time, complications, post-operative hospital stay, conversion rate, functional and cosmetic results, and we compare them with conventional laparoscopic pyeloplasty. Conclusions: More reported series are necessary but it has been proved that minilap pyeloplasty is a reproducible and safe technique with excellent results

Pieloplastia por Minilap / Mini-laparoscopic pyeloplasty

Los continuos avances en el campo de la laparoscopia han ido siendo introducidos progresivamente en la cirugía urológica. Con el desarrollo de instrumental de menor tamaño nace la minilaparoscopia, buscando reducir el trauma abdominal y mejorar la cosmética de las cicatrices, obteniendo unos resultados similares o mejores a los logrados en la laparoscopia convencional. Objetivo: El objetivo es evaluar los resultados y la reproducibilidad de la pieloplastia por minilap. Método: Para ello se ha realizado una revisión de la literatura y una búsqueda bibliográfica en PubMed. Describimos la técnica quirúrgica realizada en el Hospital Universitario Marqués de Valdecilla, Santander (HUMV). Resultados: se encontraron más de 60 artículos que hacían referencia a la minilaparoscopia. Aunque a día de hoy son escasas las series reportadas de pieloplastia por minilap, estas ofrecen unos resultados excelentes. Analizamos los datos de tiempo quirúrgico, complicaciones, estancia hospitalaria, tasa de conversión, resultado funcional y cosmético, comparándolos con la pieloplastia laparoscópica convencional. Conclusiones: Aunque es necesario que se reporten más series, se ha demostrado que la pieloplastia por minilap es una técnica reproducible y segura, que otorga así mismo unos resultados excelentes

Continued progresses in the field of laparoscopy have been introduced in urological surgery. With the development of smaller instrumental minilaparoscopy was born seeking to reduce abdominal trauma and improve cosmetic scars, obtaining similar or better results than conventional laparoscopy. Objective: The objective of this paper is to evaluate the results and reproducibility of mini-laparoscopic pyeloplasty. Methods: A literature review and a bibliographic search in PubMed were performed. We describe the technique used in the "Hospital Marqués de Valdecilla" (HUMV), Santander (Spain). Results: 60 articles about mini-laparoscopy were found. Although there are few reported minilap pyeloplasty series, they offer excellent cosmetic and functional results. We analyze operative time, complications, post-operative hospital stay, conversion rate, functional and cosmetic results, and we compare them with conventional laparoscopic pyeloplasty. Conclusions: More reported series are necessary but it has been proved that minilap pyeloplasty is a reproducible and safe technique with excellent results

[Expert opinion about the use of transdermic oxybutynin in Spain for the treatment of adult overactive bladder.] / Opinión de expertos sobre el uso de la oxibutinina transdérmica en España para el tratamiento de la vejiga hiperactiva en adultos.

OBJECTIVES: To define the different characteristics of transdermal oxybutynin (TO) for the treatment of overactive bladder in adults, to know the barriers for the use of this drug and to establish proposals to minimize these barriers. METHODS: Local sessions were held with 111 urologists from all over the country divided into 12 sessions. They were moderated by a brainstorming technique led by an external consultant. RESULTS: 75% of experts believe that tolerability and clinical efficacy (50%) are the most important attributes to choose this formulation, being the lack of scientific publications the least valued (12%). These opinions were based on their own clinical experience with TO or on scientific publications, without establishing comparison with other treatment options. The main barriers would be administrative obstacles (84%), difficulty in its use (54%) and the lack/rejection of the transdermal administration by the patient (33%). Actions were proposed to correct the 8 most significant barriers, such as better training for specialists (both Urology and other specialties) and for patients, creating informative materials to reinforce health education in managing patches, generating greater volume of scientific evidence to support their use in overactive bladder and clearly identifying the profile of patients who will benefit most from this therapeutic strategy. CONCLUSIONS: Although oxybutynin has been standard treatment of overactive bladder in recent years the conclusion of this working group is that its new transdermal formulation offers a better-tolerated alternative for patients, and, therefore the necessary tools to generate more evidence should be implemented to increase the proper use among specialists and patients.

Opinión de expertos sobre el uso de la oxibutinina transdérmica en España para el tratamiento de la vejiga hiperactiva en adultos / Expert opinión about the use of transdermic oxybutynin in Spain for the treatment of adult overactive bladder

OBJETIVO: Definir las características diferenciales de la oxibutinina transdérmica (OT) en el tratamiento de la vejiga hiperactiva en pacientes adultos, conocer las barreras de uso y establecer propuestas para minimizar estas barreras. MÉTODOS: Se realizaron 12 sesiones de ámbito local a las que acudieron 111 urólogos en total de todo el territorio nacional, que fueron moderadas mediante una técnica de brainstorming dirigida por un consultor externo. RESULTADOS: El 75% de los expertos opina que la tolerabilidad y la eficacia clínica (50%) son los 'atributos' más importantes para escoger esta formulación, siendo el menos valorado la escasez de publicaciones científicas (12%), basándose en su propia experiencia clínica con OT o la referida en publicaciones científicas, sin establecer comparación con otras alternativas de tratamiento. Las principales 'barreras' para su uso serían las trabas administrativas (84%), la dificultad en su manejo (54%) y el desconocimiento-rechazo de la vía transdérmica por parte del paciente (33%). Se acordaron acciones para subsanar las 8 barreras más significativas, como mayor formación para especialistas (tanto Urología como otras especialidades) y para pacientes, creación de materiales informativos para reforzar la educación en el manejo de parches, generar mayor volumen de evidencia científica que avale su uso en la vejiga hiperactiva e identificar claramente los perfiles de pacientes más beneficiarios de esta estrategia terapéutica. CONCLUSIONES: Este grupo de expertos identificó la tolerabilidad y eficacia como los dos atributos clave que debe tener un fármaco para el tratamiento de la vejiga hiperactiva, de los cuales la OT destaca en el primero de ellos. Además, deben emprenderse acciones formativas, educativas y de investigación a todos los actores implicados con el fin de superar las barreras que dificultan el correcto manejo de este fármaco

OBJECTIVES: To define the different characteristics of transdermal oxybutynin (TO) for the treatment of overactive bladder in adults, to know the barriers for the use of this drug and to establish proposals to minimize these barriers. METHODS: Local sessions were held with 111 urologists from all over the country divided into 12 sessions. They were moderated by a brainstorming technique led by an external consultant. RESULTS: 75% of experts believe that tolerability and clinical efficacy (50%) are the most important attributes to choose this formulation, being the lack of scientific publications the least valued (12%). These opinions were based on their own clinical experience with TO or on scientific publications, without establishing comparison with other treatment options. The main barriers would be administrative obstacles (84%), difficulty in its use (54%) and the lack/rejection of the transdermal administration by the patient (33%). Actions were proposed to correct the 8 most significant barriers, such as better training for specialists (both Urology and other specialties) and for patients, creating informative materials to reinforce health education in managing patches, generating greater volume of scientific evidence to support their use in overactive bladder and clearly identifying the profile of patients who will benefit most from this therapeutic strategy. CONCLUSIONS: Although oxybutynin has been standard treatment of overactive bladder in recent years the conclusion of this working group is that its new transdermal formulation offers a better-tolerated alternative for patients, and, therefore the necessary tools to generate more evidence should be implemented to increase the proper use among specialists and patients

Assessment of the urodynamic diagnosis in patients with urinary incontinence associated with normal pressure hydrocephalus.

AIMS: To assess the urodynamic patterns present in patients with adult normal pressure hydrocephalus (NPH) in our institution. METHODS: Retrospectively conducted study on patients diagnosed with NPH by the Neurosurgery Department of our institution, without etiological treatment or urogynecological disorders, who underwent an urodynamic study (UDS) performed according to methods proposed by the International Society of Continence (ICS). Clinical information, complementary tests and UDS were collected, and descriptive analysis was performed, with special focus in urodynamic final diagnosis. RESULTS: Eighty-one UDS performed between 2003 and 2013. Fifty-one Males (63%). Mean age: 74.89 ± 8.58 years old (range 52-88 years). Classical triad of symptoms: gait disturbance, dementia, and urinary incontinence (UI) presented in 48.1%. Urinary urgency in 80.9% and UI in 70%. In two cases (2.5%) UDS was not valuable. Urodynamic features of the 79 remaining studies revealed overactive detrusor (OD) in 56 patients (70.9%), being associated with Stress UI (SUI) in one case and with bladder outlet obstruction (BOO) in 19. SUI in six patients (7.6%) and BOO in five (6.3%). Detrusor underactivity in four cases (5%) and normal study in eight (10.1%). About 47.1% of males presented BOO. Cerebrospinal fluid shunt surgery was performed on 32 patients during follow-up, with subsequent clinical improvement in 90.6% of them. CONCLUSIONS: OD was the most frequent diagnosis within UDS conducted on adult NPH patients in our institution, with BOO in an elevated percentage of them. Etiological treatment led to symptomatic improvement in most of patients.

Carcinoma urotelial de pelvis renal en riñón ectópico presacro / Transitional Cell Carcinoma of the Renal Pelvis on Presacral Ectopic Kidney

No disponible

Bladder endometriosis and endocervicosis: presentation of 2 cases with endoscopic management and review of literature.

Urinary tract endometriosis and endocervicosis are an uncommon pathologic finding, with a common embryological origin. We present 2 cases of female patients with bladder mass. The first one was a finding of a nodular formation in the bladder during study of a nonviable foetus and the second was an incidental finding of a neoformation in the fundus of the bladder during the realization of an ultrasound. In both cases, we performed a surgical management with transurethral resection. Histopathological examination revealed a bladder endometrioma in the first case and endocervicosis with associated endometriosis in the second.

Microvejiga tras BCG / Microbladder after the BCG therapy

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Testicular reconstruction after testicular rupture and review of the literature.

OBJECTIVE: To report a clinical case of testicular rupture and review of the literature published. METHOD: A 15 years old male with a testicular rupture after a sports injury was diagnosed by Doppler ultrasound. RESULTS: Surgical exploration was performed and the tear was repaired. He had a benign postoperative course. The patient presents a normal size testicle after a year of follow-up. CONCLUSIONS: Testicular rupture is an uncommon but important entity that may occur. It is essential early diagnosis and e management to avoid orchiectomy.

Reparación tras rotura testicular y revisión de la literatura / Testicular reconstruction after testicular rupture and review of the literature

OBJETIVO: Describir nuestro caso clínico de rotura testicular y revisión de la literatura. MÉTODO: Varón de 15 años que sufre rotura testicular tras accidente deportivo que fue diagnosticada por ecografía doppler. RESULTADOS: Se realiza exploración quirúrgica y se repara la fractura. Buena evolución postoperatoria. Conservación del 75 % del tamaño testicular. CONCLUSIONES: La rotura testicular es una entidad infrecuente pero importante por las secuelas que puede producir. Es fundamental un diagnóstico y tratamiento precoz para evitar la orquiectomía (AU)

OBJECTIVE: To report a clinical case of testicular rupture and review of the published literature. METHODS: A 15 year old male with a testicular rupture after a sport injury was diagnosed by Doppler ultrasound. RESULTS: Surgical exploration was performed and the tear was repaired. He had a benign postoperative course. The patient presents a normal size testicle after a year of follow-up. CONCLUSIONS: Testicular rupture is an uncommon but important entity that may occur. It is essential early diagnosis and management to avoid orchiectomy (AU)